“Two eminent scientists mentioned that the endocannabinoid system is concerned in basically all human illness,” mentioned Mechoulam. “It is a very robust assertion, however it appears to be right.”
The endocannabinoid system, abbreviated as ECS, was discovered in 1992, that is a few years after the opposite techniques had discovered their approach to medical textbooks. To convey all to hurry, the opposite techniques embody:
- The respiratory system
- The circulatory system
- The integumentary system
- The renal system
- The digestive system
- The musculoskeletal system
- Reproductive system
- The nervous system
- Endocrine system
- Lymphatic system
Along with the profound ECS, we now have 11 techniques which were recognized within the human physique.
The ECS is made up of three main elements; endocannabinoids, endocannabinoid receptors, and metabolize enzymes that degrade the endocannabinoids.
Endocannabinoids are related in some ways to neurotransmitters. Nevertheless, they’re produced fairly in a different way. Whereas most neurotransmitters are produced and saved in vesicles, endocannabinoids are produced on demand.
This being a “newish system,” its mechanisms haven’t been absolutely elucidated. Nevertheless, it’s clear that the ECS is answerable for sustaining physiological steadiness within the physique aka homeostasis.
In sustaining a state of homeostasis, the ECS has been implicated within the following features:
- Ache and irritation
- Hormonal management
- Immune response
- Urge for food
- Sperm production amongst others
Consequently, a dysregulation of the ECS might set off debilitating circumstances. This has been described by Dr. Ethan Russo because the medical endocannabinoid deficiency syndrome (CEDS). Conversely, when the endocannabinoid tone is preserved, the physique is ready to wade of an infection and illness.
As a lot as there’s a dearth of information on the workings of this unimaginable system, present proof means that an understanding of this method may facilitate the understanding of well being and illness. For instance, CECD has been linked to the pathology of autoimmune illnesses.  On the identical time the ECS has proven to supply a “protecting function” in opposition to many medical circumstances. Modulating the ECS may assist in the therapy of a myriad of illnesses resembling emesis, irritation, a number of sclerosis, epilepsy, glaucoma, melancholy, metabolic syndrome associated illnesses, and Alzheimer’s illness amongst others.
In abstract, the ECS seems to be a system that underpins the features of most different techniques within the physique; it has a hand in every little thing. However what’s most original about it’s its hyperlink to a plant.
As Dr. Mechoulam aptly places it:
“Through the use of a plant that has been round for hundreds of years, we found a brand new physiological system of immense significance. We wouldn’t have been capable of get there if we had not seemed on the plant.”
- Russo E. B. (2016). Medical Endocannabinoid Deficiency Reconsidered: Present Analysis Helps the Concept in Migraine, Fibromyalgia, Irritable Bowel, and Different Therapy-Resistant Syndromes. Hashish and cannabinoid analysis, 1(1), 154–165.