Cannabidiol (CBD) seems to be the reigning poster youngster of hashish these days–however can it mitigate the unwanted effects of tetrahydrocannabinol (THC)? That is an space of curiosity amongst hashish scientists (and sufferers) as it may well pave manner for the event of protected cannabinoid-based medicines.
THC and CBD are widespread phytocannabinoids present in hashish that share related molecular buildings. Nevertheless, the essential distinction between them lies inside a single chemical bond.
And guess what?
That is what makes THC psychoactive (intoxicating) and CBD non-psychoactive (or non-intoxicating) as a result of it impacts the way in which every compound binds to receptors within the mind.
CBD is a allosteric modulator of the cannabinoid 1 (CB1) receptor. Whereas THC is a partial agonist at this receptor, CBD modifies the form of this receptor, thereby limiting THC’s capability to bind.
Whereas many take pleasure in THC’s results, some individuals expertise undesirable outcomes equivalent to short-term reminiscence loss and anxiousness. Moreover, sufferers who use hashish could not need to get intoxicated whereas medicating.
So, is there any method to mitigate these results, maybe by taking CBD with THC? Research (and anecdotes) level to sure.
A latest examine carried out by the College of Western Ontario recognized the mechanism via which CBD blocks unwanted effects brought on by THC.
Steven Laviolette, PhD and his group of researchers used pre-clinical fashions to check a molecule within the mind’s hippocampus (or reminiscence heart) known as extracellular-signal regulated kinase (ERK). This molecule has been related to the neuropsychiatric results of THC.
The outcomes of this examine which have been revealed within the Journal of Neuroscience confirmed the next:
- THC administration elevated ranges of activated ERK, leading to anxious habits
- CBD and THC administration normalized ERK ranges, resulting in much less anxious habits
The researchers concluded that CBD modulates the results of THC on the ERK pathway; on this manner, it mitigates THC’s results.
The outcomes from this examine and others warrant additional investigation to tell pharmaceutical software. For instance, Sativex (a cannabis-based drug), which is authorised to treat spasticity associated with multiple sclerosis in the UK, accommodates each CBD and THC in a ratio of 1:1. The addition of CBD to THC potentiates the therapeutic advantages of THC whereas attenuating a few of its negative effects.
CBD and THC maintain monumental potential for treating a mess of situations however we’re nonetheless teasing out their separate and mixed results on each the physique and mind.
1. Laprairie B. Cannabidiol is a destructive allosteric modulator of the cannabinoid CB1 receptor. Br J Pharmacol. 2015;172(20):4790-4805.
2. Laviolette S., et al. Cannabidiol counteracts the psychotropic side-effects of Δ-9-tetrahydrocannabinol within the ventral hippocampus via bidirectional management of ERK1-2 phosphorylation. Journal of Neuroscience. 2019;39(44):8762-8777.